Table 4.
Master regulators identified by transcriptomic analysis
| Transcription factor | Processes | P value | Regulated genes | |
|---|---|---|---|---|
| Nb | Examples | |||
| HNF-4α | Induction of apoptosis via death domain receptors | 2.52E-143 | 78 | LRP5, APOC3, NR1I2, PXR, ABG1, CIP1B1, CYP3A5 |
| Energy metabolism | ||||
| Response to chemical stimulus | ||||
| SP1 | Neurotransmitter uptake | 6.10E-76 | 42 | EDNRB, KRT16, TNNT2, PGE2R2, PGF2aR, nAChR alpha-5 and alpha-4 |
| Intermediate filament cytoskeleton organization and biogenesis | ||||
| Ketone body biosynthetic process | ||||
| P53 | DNA damage response, signal transduction resulting in induction of apoptosis | 1.51E-37 | 21 | BCL2L1, CREBBP, CDC6, CHEK2, DAXX, BCL2A1, BBC3 |
| Regulation of mitochondrial membrane permeability | ||||
| DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis | ||||
| c-Myc | DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis | 9.74E-36 | 20 | BBC3, NOTCH1, BCL-3 |
| Induction of apoptosis by intracellular signals | ||||
| Release of cytochrome c from mitochondria | ||||
| AP-1 | Cell death | 1.58E-28 | 16 | CBP, DAXX, IL-3 |
| Regulation of apoptosis | ||||
| Regulation of apoptosis | ||||
| c-Jun | Regulation of survival gene product activity | 9.91E-27 | 15 | CBP, DAXX, IL-3 |
| Regulation of biological quality | ||||
| Catecholamine uptake during transmission of nerve impulse | ||||
| CREB1 | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 6.16E-25 | 14 | IL-4, NPR1, SOX15 |
| Regulation of cellular metabolic process | ||||
| Regulation of transcription | ||||
| ESR1 | Steroid hormone receptor signalling pathway | 3.80E-23 | 13 | ABCC11, CYP1B1, CYP7B1 |
| Oestrogen receptor signalling pathway | ||||
| Regulation of transcription, DNA-dependent | ||||
| HNF1-alpha | Catecholamine transport | 3.80E-23 | 13 | APOC3, Fibrinogen alpha, Anithrombin III |
| Positive regulation of cellular process | ||||
| Catecholamine uptake during transmission of nerve impulse | ||||
| NF-kB | Regulation of apoptosis | 2.33E-21 | 12 | SOD2, DAXX, Pim-2 |
| Response to stress | ||||
| Regulation of programmed cell death | ||||
Transcription factors identified by MetaCore are presented. Transcription factors are organized by a major biological process in which they are involved, P value assigned by MetaCore, number of genes present in the array that they potentially regulate and examples of these genes