Table 3.
Genotype frequencies in Korean patients with colorectal cancer and controls
| Gene/SNP | Case/cont | ORa (95% CI) | ORb (95% CI) |
|---|---|---|---|
| SOD2 | |||
| RS4880 | |||
| AA | 665/583 | 1.0 | 1.0 |
| GA | 145/128 | 1.01(0.77–1.31) | 0.98 (0.74–1.29) |
| GG | 9/9 | 0.85 (0.33–2.17) | 0.96 (0.36–2.56) |
| P for trend | 0.918 | 0.854 | |
| SELS | |||
| RS34713741 | |||
| CC | 284/283 | 1.0 | 1.0 |
| CT | 441/351 | 1.24 (0.99–1.54) | 1.25 (0.99–1.57) |
| TT | 73/70 | 1.04 (0.72–1.50) | 1.05 (0.71–1.56) |
| P for trend | 0.277 | 0.261 | |
| SEPP1 | |||
| RS3877899 | |||
| CC | 797/710 | 1.0 | 1.0 |
| CT | 5/1 | 5.02 (0.58–43.56) | 5.99 (0.67–53.83) |
| SEPP1 | |||
| RS7579 | |||
| CC | 409/363 | 1.0 | 1.0 |
| CT | 270/239 | 0.98 (0.71–1.06) | 0.98 (0.77–1.25) |
| TT | 66/67 | 0.86 (0.60–1.25) | 0.93 (0.62–1.39) |
| P for trend | 0.516 | 0.856 | |
| SEP15 | |||
| RS5845 | |||
| GG | 793/707 | 1.0 | 1.0 |
| GA | 34/25 | 1.20 (0.71–2.04) | 1.31(0.75–2.29) |
| P | 0.498 | 0.338 | |
| SEP15 | |||
| RS5859 | |||
| CC | 790/705 | 1.0 | 1.0 |
| CT | 34/25 | 1.20 (0.71–3.04) | 1.31(0.75–2.30) |
| P | 0.496 | 0.337 | |
| GPX4 | |||
| RS713041 | |||
| CC | 339/275 | 1.0 | 1.0 |
| CT | 356/325 | 0.89 (0.72–1.11) | 0.94 (0.74–1.18) |
| TT | 101/97 | 0.85 (0.62–1.18) | 0.95 (0.67–1.34) |
| P for trend | 0.240 | 0.659 | |
| GPX1 | |||
| RS1050450 | |||
| CC | 637/547 | 1.0 | 1.0 |
| CT + TT | 115/121 | 0.81(0.61–1.07) | 0.89 (0.66–1.20) |
Cases and controls were genotyped for the nine SNPS indicated and multivariate logistic regression was used to assess the relationship between each variant and CRC risk. Adjusted mean odds ratios (OR) with 95% confidence limits are shown. P for trend values (and P values for rs 5845 and 5859 where there are only two values) are indicated in italics
aAdjusted for age and sex
bAdjusted for age, sex, intake of aspirin, intake of multivitamins, family history of colorectal cancer, smoking, alcohol, intake of red meat, vegetables and fruit, and physical activity