Table 4.
Genotype frequencies in Korean patients with colorectal cancer and controls stratified according to disease subsite
| Gene/SNP | Colon cancer | Rectal cancer | ||||
|---|---|---|---|---|---|---|
| Case/cont | ORa (95% CI) | ORb (95% CI) | Case/cont | ORa (95% CI) | ORb (95% CI) | |
| SOD2 | ||||||
| RS4880 | ||||||
| AA | 305/583 | 1.0 | 1.0 | 278/583 | 1.0 | 1.0 |
| GA | 66/128 | 0.99 (0.72–1.38) | 0.96 (0.68–1.36) | 65/128 | 1.08 (0.78–1.51) | 1.04 (0.74–1.48) |
| GG | 6/9 | 1.26 (0.44–3.58) | 1.45 (0.49–4.30) | 3/9 | 0.69 (0.19–2.59) | 0.79 (0.20–3.05) |
| P for trend | 0.851 | 0.905 | 0.867 | 0.961 | ||
| SELS | ||||||
| RS34713741 | ||||||
| CC | 143/283 | 1.0 | 1.0 | 111/283 | 1.0 | 1.0 |
| CT | 203/351 | 1.12 (0.86–1.47) | 1.09 (0.82–1.44) | 187/351 | 1.35 (1.01–1.79) | 1.40 (1.04–1.89) |
| TT | 23/70 | 0.65 (0.39–1.09) | 0.63 (0.37–1.07) | 40/70 | 1.46 (0.93–2.29) | 1.57 (0.98–2.51) |
| P for trend | 0.525 | 0.397 | 0.032 | 0.018 | ||
| SEPP1 | ||||||
| RS3877899 | ||||||
| CC | 369/710 | 1.0 | 1.0 | 337/710 | 1.0 | 1.0 |
| CT | 1/1 | 0.266 (0.16–43.2) | 3.21 (0.20–52.7) | 2/1 | 4.74 (0.42–53.1) | 5.35 (0.47–61.5) |
| SEPP1 | ||||||
| RS7579 | ||||||
| CC | 190/363 | 1.0 | 1.0 | 176/363 | 1.0 | 1.0 |
| CT | 121/239 | 0.95 (0.72–1.26) | 0.95 (0.70–1.27) | 111/239 | 0.94 (0.70–1.25) | 0.99 (0.73–1.36) |
| TT | 32/67 | 0.90 (0.57–1.42) | 0.96 (0.59–1.57) | 26/67 | 0.78 (0.48–1.27) | 0.86 (0.51–1.45) |
| P for trend | 0.634 | 0.863 | 0.331 | 0.728 | ||
| SEP15 | ||||||
| RS5845 | ||||||
| GG | 368/707 | 1.0 | 1.0 | 333/707 | 1.0 | 1.0 |
| GA | 14/25 | 1.08 (0.55–2.10) | 1.17 (0.58–2.35) | 15/25 | 1.24 (0.64–2.38) | 1.33 (0.67–2.64) |
| P | 0.827 | 0.658 | 0.524 | 0.411 | ||
| SEP15 | ||||||
| RS5859 | ||||||
| CC | 369/705 | 1.0 | 1.0 | 329/705 | 1.0 | 1.0 |
| CT | 14/25 | 1.07 (0.55–2.09) | 1.16 (0.58–2.34) | 15/25 | 1.25 (0.65–2.41) | 1.34 (0.68–2.66) |
| P | P for trend | 0.84 | 0.671 | 0.507 | 0.399 | |
| GPX4 | ||||||
| RS713041 | ||||||
| CC | 160/275 | 1.0 | 1.0 | 131/275 | 1.0 | 1.0 |
| CT | 161/325 | 0.85 (0.65–1.12) | 0.93 (0.70–1.71) | 159/325 | 1.03 (0.78–1.37) | 1.07 (0.79–1.44) |
| TT | 50/97 | 0.89 (0.60–1.32) | 1.01 (0.67–1.55) | 42/97 | 0.90 (0.59–1.37) | 0.99 (0.64–1.56) |
| P for trend | 0.367 | 0.906 | 0.74 | 0.874 | ||
| GPX1 | ||||||
| RS1050450 | ||||||
| CC | 385/547 | 1.0 | 1.0 | 271/547 | 1.0 | 1.0 |
| CT + TT | 53/121 | 0.80 (0.56–1.14) | 0.89 (0.61–1.29) | 48/121 | 0.80 (0.55–1.15) | 0.89 (0.60–1.30) |
Multivariate logistic regression was used to assess the relationship between each genetic variant and CRC risk. Adjusted mean odds ratios (OR) with 95% confidence limits are shown and those in bold indicate they are statistically significant. P for trend values (and P values for rs 5845 and 5859 where there are only two values) are indicated in italics
aAdjusted for age and sex
bAdjusted for age, sex, intake of aspirin, intake of multivitamin, family history of colorectal cancer, smoking, alcohol, intake of red meat, vegetables and fruits, and physical activities