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. 2010 Sep 6;190(5):881–892. doi: 10.1083/jcb.200911078

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© 2010 Tang et al.

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Figure 3. — Inhibition of autophagy by cytoplasmic HMGB1. Hmgb1^−/− and Hmgb1^+/+ MEFs were enucleated by centrifugation after cytochalasin B treatment as described in Materials and methods and then were treated with HBSS for 3 h, and LC3 punctae formation was detected by a confocal microscope. (A) Representative images of LC3 punctae (white arrows) and HMGB1 (red arrows) in cytoplasts of Hmgb1^−/− and Hmgb1^+/+ MEFs are depicted. (B) The percentage of cells showing accumulation of LC3 punctae was reported (*, P < 0.05; n = 3). Data are means ± SEM.