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. 2001 Jan 30;98(4):1912–1917. doi: 10.1073/pnas.041596398

Figure 2.

Figure 2

Effect of the NK1R antagonist RP67580 on anxiety-related behaviors. (a) EPM: diazepam (DZ) and both doses of RP67580 (RP) significantly decreased anxiety-related measures in +/+ mice, whereas only diazepam was effective in −/− (n = 9–10 mice group). (b) USV: the two doses of RP67580 produced a significant decrease in the number of vocalizations in +/+ mice whereas they had no effect in the −/− mice. Diazepam caused a significant decrease in vocalization in both genotypes. ANOVA revealed a main effect of treatment and an interaction of genotype and treatment in all measures presented. Significant differences between groups were calculated by Fisher post hoc analysis (*, P < 0.05; **, P < 0.01; or ***, P < 0.001).