Table 1.
Treatment | Survival Fraction (Mean ± SD) | % Inhibition |
Control | 1.00 | 0 |
Gemcitabine (1 nM) | 0.52 ± 0.04* | 48 |
Gemcitabine (2.5 nM) | 0.21 ± 0.01* | 79 |
Sunitinib (1 µM) | 0.64 ± 0.02* | 36 |
Gemcitabine (1 nM) + Sutent (1 nM) | 0.19 ± 0.01† | 81 |
Gemcitabine (2.5 nM) + Sutent (2.5 µM) | 0.07 ± 0.02† | 93 |
KCI-18 cells were treated with gemcitabine at 1 and 2.5 nM or sunitinib at 1 µM or both drugs in combination for 24 hours, and then cells were plated in a colony formation assay for 10 days. The mean survival fraction was calculated from triplicate wells.
P < .001.
P < .0001.