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. 2010 Oct 1;3(5):326–335. doi: 10.1593/tlo.10163

Figure 2.

Figure 2

Inhibition of EGF-triggered signaling pathways in medulloblastoma lines by AEE788. DaoyV and DaoyHER2 (A) and D283 (B) cells were serum-starved overnight and incubated with increasing concentrations of AEE788 2 hours before a 10-minute exposure to EGF (25 ng/ml). Cell lysates were subjected to immunoblot analysis with antibodies to the phosphorylated and total HER1, HER2, Akt, and ERK1/2.