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Antitumor activity of AEE788 on human medulloblastoma xenografts. Mice bearing Daoy (A), DaoyPt (B), and DaoyHER2 (C) xenografts received orally either vehicle only or AEE788 at a dosage of 50 mg/kg thrice a week for 4 weeks. Points shown are mean values for groups of 8 to 10 mice. Bars, SE. Drug activity was defined by percentage TVI. (D–F) Effects of AEE788 treatment on the body weight changes of animals bearing Daoy (D), DaoyPt (E), and DaoyHER2 (F) xenografts.
