TABLE 5.
Pharmacokinetic Parameters of Hizentra™ and IVIg
| Hizentra | IVIg* (Privigen®) | |
|---|---|---|
| Number of subjects | 18 | 18 |
| Dose* | ||
| Mean | 228 mg/kg bw | 152 mg/kg bw |
| Range | 141–381 mg/kg bw | 86–254 mg/kg bw |
| IgG peak levels | ||
| Mean | 1616 mg/dL | 2564 mg/dL |
| Range | 1090–2825 mg/dL | 2046–3456 mg/dL |
| IgG trough levels | ||
| Mean | 1448 mg/dL | 1127 mg/dL |
| Range | 952–2623 mg/dL | 702–1810 mg/dL |
| AUC† | ||
| Mean | 10560 day x mg/dL | 10320 day x mg/dL |
| Range | 7210–18670 day x mg/dL | 8051–15530 day x mg/dL |
Abbreviation: bw, body weight.
*
For IVIg: weekly-equivalent dose.
†
Standardized to a 7-day period.