TABLE 8.

Treatment Differences: Pain (Healthy Subjects)

Variable	Comparison	Difference*	Two-sided 90% CI (P value)
Maximum pain† (mm)	IgPro16 (15 mL) – Vivaglobin® IgPro20 (15 mL) – Vivaglobin® IgPro20 (12 mL) – Vivaglobin®	−2.54 −1.64 −2.43	−4.82, −0.26 (P=.0679) −3.92, 0.64 (P=.2340) −4.71, −0.15 (P=.0801)
Mean pain† (mm)	IgPro16 (15 mL) – Vivaglobin® IgPro20 (15 mL) – Vivaglobin® IgPro20 (12 mL) – Vivaglobin®	−1.41 −0.94 −1.54	−2.50, −0.33 (P=.0328) −2.02, 0.15 (P=.1545) −2.62, −0.46 (P=.0205)

^*A negative difference indicates a generally higher value of maximum/mean pain under Vivaglobin^®.

^†Pain was assessed by subjects on a 100-mm VAS; numbers given are from that scale.

Source: Adapted from Hagan 2010.