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. 2010 Sep 1;6(5):475–490. doi: 10.7150/ijbs.6.475

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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A) Representative cross-sections of the hearts of young adult Ames and age-matched wild-type (4-7mo) and old Ames and age-matched wild-type (24-28 mo) at the level of the papillary muscles, stained with Masson Trichome. The collagen is stained blue. B) Collagen Distribution in the aging of both Ames and wild-type mice. Collagen area was measured in 75 fields per group using ImageJ. Young adult wild-type hearts had 87% more median collagen by area than did the young adult Ames (* p<0.05). With advancing age, however, the percentage of tissue attributed to collagen increased more rapidly in Ames dwarf than in wild-type hearts to the point that, at 26mo, there were was no significant difference.

A) Representative cross-sections of the hearts of young adult Ames and age-matched wild-type (4-7mo) and old Ames and age-matched wild-type (24-28 mo) at the level of the papillary muscles, stained with Masson Trichome. The collagen is stained blue. B) Collagen Distribution in the aging of both Ames and wild-type mice. Collagen area was measured in 75 fields per group using ImageJ. Young adult wild-type hearts had 87% more median collagen by area than did the young adult Ames (* p<0.05). With advancing age, however, the percentage of tissue attributed to collagen increased more rapidly in Ames dwarf than in wild-type hearts to the point that, at 26mo, there were was no significant difference.