Skip to main content
. Author manuscript; available in PMC: 2010 Sep 8.
Published in final edited form as: Anesthesiology. 2010 Mar;112(3):623–630. doi: 10.1097/ALN.0b013e3181cf894a

Fig. 4.

Fig. 4

Xenon activates wild-type but not mutant KATP channels in inside-out patches. (A, B) Xenon enhanced Kir6.2/SUR1 currents, but not Kir6.2-K185Q/SUR1 currents, in the presence of adenosine triphosphate (ATP). Note that 1 mm ATP increased Kir6.2-K185Q/SUR1 currents because of MgATP-dependent refreshment15,23 and because of its interaction with the SUR1 subunit in the presence of MgCl2.24 (C) Mean data from recordings as shown in A and B. The slope conductance (G) in the presence of ATP and xenon is expressed as a fraction of the conductance in the absence of the drug (Gc). Xenon activation of Kir6.2/SUR1 increased with increasing ATP concentrations but was absent in the Kir6.2-K185Q mutant both in the absence and presence of ATP. Numbers (N) are given above the bars. ** P < 0.01 compared with control.