Table 1.

Arginine Metabolites in SCD vs. controls. Values indicate median plasma levels at steady state in micromolar. Results are compared for control subjects compared to all SCD patients, and then the same SCD patients categorized by genotype.

Arginine Metabolite	Control (n=29)	All SCD (n=177)	SS (n=130)	Sβ⁰-thal (n=3)	SC (n=34)	Sβ⁺-thal (n=8)
ADMA	0.31	0.94 ^***	0.99^***	1.48^***	0.82^***	0.78
SDMA	0.83	1.02 ^***	1.03^**	1.04	0.92	0.98
L-NMMA	0.13	0.18 ^***	0.18^***	0.23	0.15	0.17
L-Arginine	78.3	46.4 ^***	45.5^***	28.5^*	51.5^**	42.7^**
NOHA	2.50	1.93 ^**	1.80^*	2.15	2.23	2.11
Citrulline	20.1	17.7 ^*	17.0^*	19.1	21.1	20.6

p<0.05 compared to control

^**

p<0.01

^***

p<0.001; Mann-Whitney test for all SCD compared to control subjects; Kruskal-Wallis test with Dunne’s post-test for comparisons of genotype categories to control subjects.