Table 3. Arginine Metabolites in Pulmonary Hypertension.

Values indicate median plasma levels of arginine metabolites (in μmol/L) at steady state. Patients are categorized by Doppler echocardiographic measurement of tricuspid regurgitant jet velocity of < 2.5 m/sec (no PH, n=81), 2.5 – 2.9 m/sec (mild PH, n=26), or > 2.9 m/sec (moderate – severe PH, n=11). The comparison includes patients with homozygous sickle cell disease with serum creatinine levels < 220 μmol/L (Kruskal-Wallis test).

Arginine Metabolite	No PH	Mild PH	Mod-Severe PH	p
ADMA	0.95	1.18	1.14	0.02
SDMA	0.96	1.11	1.17	0.008
L-NMMA	0.18	0.19	0.16	NS
L-Arginine	45	40	52	NS
NOHA	1.7	1.7	2.9	0.005
Citrulline	16	16	21	NS