Table 4. Correlations of arginine metabolites to clinical markers.

Values shown are the Spearman correlation coefficients of the respective arginine metabolites to the indicated clinical variables in patients with homozygous sickle disease without significant renal insufficiency. Blank cells indicate nonsignificant (p>0.05) correlations.

Category	Variable	n	ADMA	SDMA	L-NMMA	NOHA
Pulmonary	NT-proBNP	117	0.24**	0.30**	-	0.21*
	Oxygen saturation	69	−0.48***	−0.46***	−0.25*	−0.42***
Blood pressure	Systolic blood pressure	104	-	-	-	0.23*
	Diastolic blood pressure	104	-	-	-	0.24*
Hematologic	Leukocyte count	116	0.34***	-	0.25**	-
	Hemoglobin	116	−0.38***	−0.34***	-	-
	Reticulocyte count	109	0.39***	-	-	-
	Fetal Hemoglobin	117	−0.40***	−0.24**	−0.30*	-
	Lactate dehydrogenase	102	0.30**	0.29**	-	-
	Indirect bilirubin	116	0.23*	-	-	-
Hepatic	Alkaline phosphatase	116	0.24**	0.27**	0.22*	-
	Alanine aminotransferase	116	0.20*	-	0.22*	-
	Bilirubin, direct	116	0.39***	0.32**	0.20*	-
Renal	Creatinine	117	-	0.36***	-	0.61***
Endothelial	Soluble VCAM-1	116	0.37***	0.35***	0.29*	0.20*
	Soluble E-selectin	110	0.27**	0.28**	-	0.26**
	Plasma Arginase activity	91	0.27*	0.36***	-	-

^*p<0.05

^**p<0.01

^***p<0.001