TABLE I.

Larger series (>50 patients) studying radical prostatectomy in men with high-risk prostate cancer

Reference	Pts (n)	Pathologic		SV + (%)	Margins + (%)	Adjuvant therapy (%)
		T2 (%)	N+ (%)
Lavery et al., 20108,a	123	42	2	32	31	26
Spahn et al., 20109	372	15	37	43	57	80
Zlotta et al., 201010	47	51	13	30	21	12.8
Ham et al., 200911,a	121	21	24	—	49	—
Shikanov et al., 200812,a	72	47	13	14	24	13
Freedland et al., 200713	58	9	31	29	22	46
Bastian et al., 200614
Johns Hopkins University	220	25	17	25	29	73
SEARCH	149	51	6	22	47	72
Carver et al., 200615	176	30	19	34	30	36
Donohue et al., 200616	238	34	18	26	26	61
Ward et al., 200517	842	27	27	—	56	76
Manoharan et al., 200318	79	30	3	28	41	38
Van Poppel et al., 200019,b	158	13	11	16	60	30
van den Ouden et al., 199820	83	18	12	40	66	0
Gerber et al., 199721	298	9	31	11	—	40
Lerner et al., 199522	812	17	33	18	—	50

^aRobot-assisted laparoscopic radical prostatectomy.

^bcT3a: 47 patients; pathologic N+: 10%; sv+: 6%; margins+: 53%.

Pts = patients; N+ = lymph node–positive; sv = seminal vesicle; + = positive; search = Shared Equal Access Regional Cancer Hospital database.