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. 2007 Aug 24;7:15.

Figure 4.

Figure 4

Spectrum of immunohistochemical staining of mAb M3H67 (to MAGE-A3) in placenta of week 6 (A-J) and week 36 (K-O). (A) Villi displaying both immunopositive and immunonegative trophoblast. (B) Villus with negative trophoblast. (C) Villus with immunopositivity of cytotrophoblast (thick arrows) as well as syncytiotrophoblast (thin arrows); note the negative villous stroma (*). (D) Villus with M3H67-positive cytotrophoblast (thick arrows) and M3H67-negative (thin arrows) syncytiotrophoblast. (E) Villus with immunonegative cytotrophoblast (thick arrows) and immunopositive (thin arrows) syncytiotrophoblast. (F) Villus with transition (arrows) from area with immunopositive cytotrophoblast/immunopositive syncytiotrophoblast to area with immunonegative cytotrophoblast/immunopositive syncytiotrophoblast. (G) Anchoring villi with immunopositive villous trophoblast and mostly immunopositive cell column with single immunonegative extravillous trophoblast cells. (H) Anchoring villi with immunonegative villous trophoblast and focal immunostaining of extravillous trophoblast of cell column. Immunonegative (I) and homogenous immunopositive area of proliferating trophoblast of cell column (J). Villous placental tissue of week 36 (K-O), with immunopositive (K, L) and immunonegative (M, N) villous trophoblast, as well as heterogeneous M3H67 immunoreactivity of the extravillous trophoblast of the basal plate (O).