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CTLA-4 blockade results in significant tumor regression in some patients. MRI images of the cervicothoracic spine from a patient with metastatic malignant melanoma which reveal enhancing intraspinal metastases with extensive cord edema prior to treatment with CTLA-4 blockade. Post-therapy images demonstrate complete resolution of the metastases and the accompanying edema. [Adapted from Hodi et al. (170)]
