Figure 3.

Structure and sequence of HERV-H Xp22. (A) Schematic representation of the predicted open-reading frames located between the 5' and 3' LTR (direct repeat) as provided by RetroSearch.dk (HERV ID 1879; 47). Several ORFs are predicted to code for Gag and Pol. The boxed Gag region corresponds to the sequence identified in several cancer lesions. (B) Gag coding sequence and corresponding amino acid sequence. Note the presence of the stop codon TAG leading to the premature termination of the protein. (C) Alignment of the translated Gag protein sequence with the Gag of HERV-H 3q26, its closest homologue as determined by BLAST.