Fig. 11. Use of PDT to treat mouse burn infection caused by bioluminescent A. baumannii.
Bacterial luminescence of a representative mouse burn infected with A. baumannii and treated with PDT at 30 minutes after infection (top row), a mouse burn treated with PS only (dark control, middle row), and a mouse burn treated with light only (light control, bottom row). After 240 J/cm2 red light had been delivered (40 minutes irradiation time at an irradiance of 100 mW/cm2), PDT induced an approximately 3-log-unit reduction in bacterial luminescence from the mouse burn, while during the same period of time, only modest reduction of bacterial luminescence was observed in the dark control and the light control.