Skip to main content
. 2010 Jul 8;19(19):3702–3720. doi: 10.1093/hmg/ddq285

Figure 3.

Figure 3.

Heterozygous HdhQ200 mutation causes a loss of striatal dopamine D1 and D2 receptor expression. (A) The 80-week-old heterozygous HdhQ200 mice exhibit a 47% decrease in D1 receptor binding in both dorsal and ventral striata. (B) Heterozygous HdhQ200 mice exhibit similar decreases in D2 receptor binding in both dorsal and ventral striata. (C) Heterozygous HdhQ200 mice show no differences in GABAA/benzodiazepine receptor binding, which surveys the integrity of extrastriatal regions. Frontal cortex (Fr. Ctx), hippocampus (Hipp), thalamus (Thal) and cerebellum (Cer). Error bars represent the SEM, and asterisks denote P < 0.05.