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. 2010 Jul 8;19(19):3702–3720. doi: 10.1093/hmg/ddq285

Figure 4.

Figure 4.

Earlier loss of striatal dopamine D1 and D2 receptor expression in homozygous HdhQ200 mice. Homozygous HdhQ200 mice exhibit earlier loss of striatal D1 and D2 receptor binding sites than heterozygous HdhQ200 mice: 50 and 40% reductions in D1 and D2 receptors by 40 weeks of age (A and B). There were no differences in extrastriatal regions measured with GABAA/benzodiazepine receptor binding (C). Whole brain (Whole), Frontal cortex (Frontal Ctx), hippocampus (Hipp) and cerebellum (Cer). Error bars represent the SEM, and asterisks denote significance at P < 0.05.