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. 2010 Jul 8;19(19):3702–3720. doi: 10.1093/hmg/ddq285

Figure 9.

Figure 9.

LC3 punctae and ubiquitin co-localize with mhtt aggregates. (A) Immunofluorescence labeling of LC3 (red) in striatum of 40-week-old HdhQ200 heterozygous mice exhibited a 4-fold increase in LC3 punctae per cell compared with WT littermate controls. (B) Double labeling of LC3 punctae (red) and AF (green) shows their co-localization (yellow) in HdhQ200 heterozygous striatum at 40 weeks. (C) Double labeling of AF (green) and ubiquitin (red) demonstrated co-localization of AF and ubiquitin (yellow) in heterozygous striatum at 40 weeks. Error bars represent the SEM, and asterisk denotes P < 0.05.