Table 4. Expression of genes involved in docosahexaenoic acid biosynthesis and peroxisomal function in liver of control subjects and subjects with AD.

Gene	Control Subjects	Subjects with Alzheimer's disease	Adjusted Difference	P-value*
Symbol	Mean ± SD; N = 9	Mean ± SD; N = 14	(95% CI)
FADS2	0.02±0.029	0.016±0.0099	−0.0017 (−0.02, 0.017)	0.851
HELO1	0.011±0.012	0.006±0.0046	−0.0043 (−0.012, 0.0036)	0.265
FADS1	0.037±0.061	0.024±0.026	−0.0071 (−0.044, 0.03)	0.693
ABCD1	0.027±0.034	0.02±0.024	−0.0089 (−0.036, 0.018)	0.500
ABCD2	8e-04±0.001	0.0011±0.0013	0.00031 (−8e-04, 0.0014)	0.567
ACOX1	0.2±0.24	0.31±0.68	0.069 (−0.45, 0.59)	0.782
HSD17B4	0.18±0.045	0.14±0.046	−0.041 (−0.083, −0.00039)	0.048
PEX13	0.041±0.017	0.037±0.017	−0.0047 (−0.022, 0.012)	0.569
PEX14	0.0087±0.004	0.013±0.022	0.0029 (−0.013, 0.019)	0.700
PEX19	0.018±0.018	0.012±0.0054	−0.0055 (−0.016, 0.0051)	0.291

Abbreviations: CI, confidence interval.

*P-values for differences between means were computed by linear regression analysis after adjustment for age, gender, and RNA integrity number.

Hydroxysteroid (17-beta) dehydrogenase 4, HSD17B4; for other abbreviations see Text S1.