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. 2010 Sep 8;5(9):e12244. doi: 10.1371/journal.pone.0012244

Table 2. Folate and vitamin B12 markers in plasma before and after 2 years of intervention in the MRI subgroup.

			Placebo group		Active treatment group^a
		N	Geometric mean	95% C.I.	N	Geometric mean	95% C.I.	P value ^b
tHcy	Before	83	11.27	(10.58–12.00)	85	11.25	(10.58–11.97)	0.974
(µmol/L)	After	83	12.14	(11.40–12.93)	84	8.72	(8.29–9.17)	*<0.001*
P value ^c			*<0.001*			*<0.001*
Folate (nmol/L)	Before	83	24.2	(21.4–27.5)	85	22.4	(19.4–25.9)	0.428
	After	83	24.9	(21.4–29.1)	84	82.1	(74.6–90.4)	*<0.001*
P value ^c			0.695			*<0.001*
Vitamin B₁₂ (pmol/L)	Before	83	333	(310–357)	85	330	(303–360)	0.891
	After	83	366	(335–400)	84	672	(626–722)	*<0.001*
P value ^c			*0.018*			*<0.001*
HoloTC (pmol/L)	Before	83	68	(61–76)	85	63	(55–72)	0.406
	After	83	73	(65–82)	84	182	(162–204)	*<0.001*
P value ^c			0.116			*<0.001*
TC saturation (%)	Before	83	7.35	(6.54–8.25)	85	6.65	(5.72–7.73)	0.306
	After	83	7.17	(6.26–8.21)	84	20.42	(18.21–22.90)	*<0.001*
P value ^c			0.648			*<0.001*
Cystathionine	Before	83	0.303	(0.273–0.337)	85	0.265	(0.237–0.295)	0.082
(µmol/L)	After	83	0.350	(0.311–0.395)	84	0.215	(0.196–0.235)	*<0.001*
P value ^c			*0.002*			*<0.001*

Abbreviations: HoloTC, holotranscobalamin; TC saturation, ratio of holoTC to total TC; tHcy, plasma total homocysteine.

^a

Active treatment group received daily supplements of folic acid (0.8 mg), vitamin B₁₂ (0.5 mg) and vitamin B₆ (20 mg) for 24 months.

^b

Student's t-test for unpaired samples,

^c

Student's t-test for paired samples.