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. Author manuscript; available in PMC: 2010 Sep 8.
Published in final edited form as: Mol Cell Neurosci. 2004 Dec;27(4):477–488. doi: 10.1016/j.mcn.2004.08.003

Fig. 7.

Fig. 7

The Wnt coreceptor, LRP6, is expressed in the retina and is required for retinal development. (A) LRP6 expression detected by expression of the βgeo transgene in sections of developing mouse retina demonstrates LRP6 transcription in several layers of the retina, including the ganglion cell layer (GCL), inner nuclear layer (INL), and inner segments (IS) of the photoreceptors. There is little β-galactosidase immunoreactivity in the inner plexiform layer (IPL), outer nuclear layer (ONL), or outer segments (OS) of the photoreceptors. (B) Whole eyecups of E18 LRP6+/+ and LRP6−/− mice demonstrate the presence of a C-shaped retinal coloboma in the absence of LRP6.