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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Nature. 2010 Jun 10;465(7299):793–797. doi: 10.1038/nature09135

Figure 1.

Figure 1

Infection with Mycobacterium avium induces changes in hematopoietic stem cells.

(A) Absolute numbers of short-term HSCs (ST-HSCs), multipotent progenitors (MPPs), and long-term HSCs (KSL, Flk2−, CD34−) were determined after infection with M. avium. n=3-7. (B) LT-HSCs (side population, lineage-negative, Sca-1+, c-Kit+ (SPKLS)) were not significantly changed after infection with M. avium. Plot is representative of three independent experiments, each with n=3-5. (C) BrdU incorporation in SPKLS cells was determined at baseline and after infection. Data represent two independent experiments, each with n=2-5. (D) Engraftment efficiency was determined after transplantation of 500 SPKLS from WT or M. avium-infected WT mice into lethally irradiated WT recipients. Data represent two independent experiments, each with n=2 to 6. (E) The percentage of LT-HSCs (KSL CD150+) in the spleen was determined at baseline and 4 weeks after M. avium infection. n=4 or 5.