Table 1.
Gene expression changes in the hypothalamus from young (2 months) and old (22 months) BALB/c mice
| Accession number | Gene name | Fold change |
|---|---|---|
| Metabolic enzymes | ||
| W33716 | NADH-ubiquinone oxidoreductase KFYI subunit | 2.8 |
| Y07708 | NADH oxidoreductase subunit MWFE | 3 |
| AA109866 | NADH-ubiquinone oxidoreductase chain 4L | 2.1 |
| AA219829 | NADH-ubiquinone oxidoreductase SGDH subunit | 2.5 |
| AA521794 | Cytochrome c oxidase subunit VIIb | 2.2 |
| AA672840 | ATP synthase O subunit | 2.2 |
| C76507 | ATP synthase γ-subunit | 2.7 |
| AA003458 | Sarco/endoplasmic reticulum Ca2+-ATPase 2 | −2.9 |
| X56007 | Na/K-ATPase β 2 | −11 |
| AA106307 | H+ ATPase subunit E | −6.1 |
| AA087605 | H(+)-ATPase (mvp) | −6.9 |
| Protein processing | ||
| U05333 | Cochaperonin ‘cofactor A’ | 6.8 |
| U09659 | Mitochondrial chaperonin 10 | 2.6 |
| Z31557 | Chaperonin containing TCP-1 | 3.2 |
| AA027544 | Ubiquitin-activating enzyme E1 | 2.8 |
| AA146437 | Cathepsin S precursor, a cysteine proteinase | 3.4 |
| Z31297 | Sorting nexin 2-like protein, protein degradation | 4.8 |
| AA013993 | Prolyl olig-peptidase | 11 |
| AA020512 | Caspase 6 | 3 |
| Neuronal growth/structure | ||
| U95116 | Lissencephaly-1 protein (LIS-1) | 3 |
| V00835 | Metallothionein-I | 3.3 |
| X61452 | Cell division control-related protein 2b | 2.8 |
| AA709861 | A-X actin-like protein | 3.5 |
| L31397 | Dynamin | −3.5 |
| U27106 | Clathrin-associated AP-2 | −5.7 |
| U86090 | Kinesin heavy chain | −2.4 |
| Neuronal signaling | ||
| AA271109 | Protein phosphatase 1, regulatory subunit | 3.8 |
| X15373 | Inositol-1,4,5-triphosphate receptor | 3.5 |
| X51468 | Preprosomatostatin gene | 3 |
| D37792 | Synaptotagmin 1 | −17 |
| D50621 | PSD-95/SAP90A | −16 |
| AA048604 | Apolipoprotein E | −6.7 |
| AA068956 | Protein phosphatase PP2A | −6.1 |
| W12204 | Ca2+/calmodulin-dependent protein kinase II | −3.6 |
| X61434 | cAMP-dependent protein kinase C β | −3.1 |
| X57497 | Glutamate receptor 1 | −2.7 |
| AA710375 | N-ethylmaleimide-sensitive factor-attachment receptor | −3.4 |
| AB006361 | Prostaglandin D synthetase | −5.6 |
| Stress response | ||
| M60798 | Cu(2+)-Zn2+ superoxide dismutase | 2.9 |
| AA107471 | DnaJ homolog 2 | −6.4 |
| AA166139 | DNA repair protein | −10.4 |
| AA033408 | Damage-specific DNA-binding protein, DNA repair | −4.6 |
| D89787 | Hif like protein | −6.5 |
| U27830 | Stress-inducible protein, STI1 | −4.9 |
Each RNA sample was hybridized twice to two different arrays, and fold change values are averages of the duplicate measurements. Positive values indicate an increase, and negative values indicate a decrease in gene expression. Genes in bold are differentially expressed in both aged cortex and hypothalamus.