Fig 4.
Serial passage of vCJD prions in Tg1014 mice. Each box represents a single mouse, with its incubation period in days and PrPSc strain type indicated in color: type 1 (blue), type 2 (red), types 1 and 2 (purple), not determined (white). From center, inner ring shows the first passage with human vCJD brain homogenate, middle ring shows the second passage, and outer ring shows the third passage. For each serial passage, brain homogenate from the respective ill Tg1014 mice was prepared and inoculated into other Tg1014 mice.