Table 1.
Incubation periods for sCJD and vCJD prions in transgenic mice.*
| Tg22372† | Tg1014 | ||||
|---|---|---|---|---|---|
| MHu2M(M165V,E167Q) | MHu2M(M111V,M165V,E167Q) | ||||
| Inoculum | Case | Incubation period | n/n0 | Incubation period | n/n0 |
| sCJD | HU082 | 104 (99, 115) | 7/7 | 88 (85, 92) | 5/5 |
| HU108 | 112 (111, 122) | 7/7 | 95 (75, 102) | 7/7 | |
| HU178 | 107 (104, 111) | 27/27 | 77 (74, 81) | 16/16 | |
| vCJD | RU96/02 | 368 (368, 433) | 6/6 | 280 (228, 323) | 5/5 |
| RU96/07 | n.d. | 211 (146, 244) | 8/8 | ||
| RU96/45 | 279 (224, 363) | 13/13 | 176 (147, 242) | 13/13 | |
| RU96/80 | n.d. | 256 (222, 278) | 6/6 | ||
| RU96/110 | n.d. | 326 (264, 403) | 5/5 | ||
*
Incubation period reported as median time to disease onset in days, with 95% confidence intervals, calculated using Kaplan-Meier statistics;
n, number of mice with clinical signs of disease; n0, number of mice inoculated; mice with intercurrent illness excluded.
†
Includes previously reported data 1;
n.d., not determined.