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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: J Allergy Clin Immunol. 2010 Sep;126(3):545–551.e4. doi: 10.1016/j.jaci.2010.07.008

Table III.

Relationship between LTE4: FENO Levels and Change in Asthma Control Days Per Week *

CLIC
(N=127)		 PACT
(N=191)		 CLIC + PACT
(meta-analytic results)
(N=318)
MT FP Difference
(MT - FP)		 MT FP Difference
(MT - FP)		 MT FP Difference
(MT - FP)
Log2 (LTE4:
FENO)
     Estimate 0.2 −0.1 +0.3 0.9 −0.2 +1.2 0.2 −0.1 +0.3
     (Std. Error) (0.18) (0.18) (0.12) (0.70) (0.69) (0.98) (0.17) (0.17) (0.12)
     P-value** 0.60 0.19 0.009 0.18 0.73 0.23 0.16 0.54 0.008
Log2 LTE4
     Estimate 0.6 0.7 −0.1 0 −0.4 +0.3 0.2 0.1 0
     (Std. Error) (0.35) (0.35) (0.27) (0.35) (0.34) (0.49) (0.21) (0.24) (0.24)
     P-value** 0.09 0.05 0.73 0.89 0.27 0.50 0.30 0.61 0.98
Log2 FENO
     Estimate 0 0.4 −0.3 −0.2 0.9 −1.0 0 0.4 −0.3
     (Std. Error) (0.17) (0.17) (0.12) (0.68) (0.67) (0.95) (0.16) (0.16) (0.12)
     P-value** 0.84 0.05 0.01 0.82 0.19 0.28 0.99 0.009 0.009
1 / (Log2 FENO)
     Estimate −3.0 −4.9 +2.0 2.8 −15.0 +17.9 −2.8 −5.2 +2.1
     (Std. Error) (2.15) (2.15) (1.52) (10.60) (12.32) (16.25) (2.11) (2.12) (1.51)
     P-value** 0.17 0.02 0.20 −0.79 0.22 0.27 0.19 0.01 0.16
*

CLIC = 2nd 4 weeks of data in each treatment phase; PACT = weeks 4–8 of data after randomization to a treatment

**

P-values computed using a regression model to see if estimate (slope) is significantly different from zero. Comparison of CLIC data and CLIC+PACT data uses a mixed linear model to account for repeated measures among CLIC subjects.