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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Nat Med. 2010 Aug 29;16(9):1001–1008. doi: 10.1038/nm.2207

Figure 1. Energy balance, AMPK pathway and POMC expression.

Figure 1

(a) Western blots (left panel) for hypothalamic protein levels (middle panels) of pAMPKα, AMPKα1, AMPKα2, tAMPKα, pACCα, ACCα (lower band in the tAMPK gel), ACCβ (upper band in the tAMPK gel) and FAS and hypothalamic AMPKα1 and AMPKα2 activities (right panel) in euthyroid and hyperthyroid rats. (b–d) Hypothalamic levels of Fasn (b), malonyl-CoA content (c) and CPT1 activity (d) in euthyroid and hyperthyroid rats. (e–i) Body weight change (e), daily food intake (f), hypothalamic malonyl-CoA levels (g), Pomc mRNA levels in the ARC (h) and western blots (left panel) for hypothalamic protein levels (right panel) of pFoxO1 and pSTAT3 (i) of euthyroid and hyperthyroid rats treated ICV with vehicle or cerulenin for 4 d. ¶P = 0.1, *P < 0.05, **P < 0.01, ***P < 0.001 vs. vehicle or euthyroid vehicle; #P < 0.05 euthyroid cerulenin vs. hyperthyroid cerulenin; ###P < 0.001 hyperthyroid vehicle vs. hyperthyroid cerulenin; all data are expressed as mean ± SEM.