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. Author manuscript; available in PMC: 2011 May 2.
Published in final edited form as: Channels (Austin). 2010 MAY-JUN;4(3):203–214. doi: 10.4161/chan.4.3.11982

Figure 17.

Figure 17

The modified honeybee toxin, TPNQ (cyan), blocks wt-Kir1.1 by binding to the outer mouth of the channel at F129-Kir1.1b (yellow side chains). TPNQ also blocks the mutant channel, R128Y-Kir1.1b, but with a 100 fold higher KD, consistent with the Tyr side-chain of R128Y (cyan) impeding close approach of the toxin. picture was drawn with PYMOL from our homology model, based on Kir2.2,13 (see Methods) and the known structure of TpNQ.16