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Comparison of TPNQ dose-response curves for ROMK vs. R128Y. Binding and block of wt-Kir1.1 (ROMK) by TPNQ at external pH 7, KD = 1.5 × 10-9 M (red, open diamonds); and binding and block of R128Y-Kir1.1b by TPNQ at external pH 7, KD = 1.5 × 10-7 M (black, closed squares).
