Figure 4.

Targeting the GRK2 interactome. A better knowledge of the determinants of the functional interactions of GRK2 with different signalling proteins may help to design novel strategies in order to specifically target GRK2 interfaces with selective partners (receptors, G protein subunits or other components of the GRK2 interactome) relevant for particular cellular functions. The structure of GRK2 in complex with Gβγ and Gαq (Tesmer et al., 2005) is shown. See text for details. GRK, G protein-coupled receptor kinase.