Table 1.
Relative affinities/potencies of MDMA, MDA and MDEA at adrenoceptors and monoamine transporters
| Site | Response | Order of potency/affinity | Reference |
|---|---|---|---|
| α1A | Binding | MDEA > MDA > MDMA | Bexis and Docherty, 2006 |
| α1A | Contraction | MDA > MDMA > MDEA+ | Bexis and Docherty, 2006 |
| α1D | Contraction | MDA > MDMA > MDEA+ | Bexis and Docherty, 2006 |
| α2A | Pre-synaptic | MDMA > MDA > MDEA | Bexis and Docherty, 2006 |
| α2A | Binding | MDMA > MDA > MDEA | Bexis and Docherty, 2006 |
| SERT | 5-HT release | MDA > MDMA > MDEA | Schmidt, 1987 |
| DAT | DA release | MDMA > MDA > MDEA | Schmidt, 1987 |
| NET | NA release | MDMA = MDA > MDEA | Cleary and Docherty, 2003 |
+
MDEA acts as partial agonist/antagonist.
Abbreviations: binding, ligand binding studies; DAT, dopamine transporter, NET, noradrenaline transporter; pre-synaptic, pre-synaptic/pre-junctional inhibition of nerve-evoked contraction; SERT, serotonin transporter.