Table 3.
Functional antagonistic potencies of AE9C90CB, tolterodine, oxybutynin, solifenacin and darifenacin in rat bladder strips
| Compound | pKB |
|---|---|
| Bladder (M3) | |
| AE9C90CB (n = 16) | 9.13 ± 0.12 |
| Tolterodine (n = 16) | 8.67 ± 0.08* |
| Oxybutynin (n = 13) | 9.05 ± 0.19 |
| Solifenacin (n = 8) | 7.94 ± 0.09* |
| Darifenacin (n = 7) | 8.55 ± 0.15* |
Functional antagonism is expressed as pKB (mean ± SEM); n, number of experiments.
*
(P < 0.05) significantly different from value for AE9C90CB tolterodine; comparative potency ratio of AE9C90CB versus tolterodine: 3; comparative potency ratio of AE9C90CB versus oxybutynin: 1; comparative potency ratio of AE9C90CB versus solifenacin: 15; comparative potency ratio of AE9C90CB versus darifenacin: 4.