Figure 2.

Effect of 50 or 100 mg oral sildenafil combined with forearm SNP iontophoresis (20 µA during 20 min) on forearm CVC (mV·mm Hg⁻¹). Oral sildenafil was taken 1 h before the iontophoresis onset. CVC was expressed as a percentage of maximal CVC at 44°C. Data from an adjacent control region of interest were subtracted from the iontophoresis region of interest to take into account any potential basal CVC variation induced by sildenafil alone. The increased CVC following SNP iontophoresis was significantly higher after 100 mg oral sildenafil than control (P = 0.03), as measured by the AUC over 60 min.