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. 2010 Jul;160(5):1135–1143. doi: 10.1111/j.1476-5381.2010.00748.x

Figure 3.

Figure 3

Effect of ODQ and/or NO donors on sildenafil-induced relaxation on carbachol-induced human detrusor contraction. (A) Concentration–response curves to sildenafil or vehicle were performed in the presence of SNAP (10 µM; N = 10) or ODQ (10 µM; N = 17) or their combination (N = 7) or their respective vehicle (N = 20) on carbachol (1 µM)-induced detrusor contraction. (B) Concentration–response curves to sildenafil or vehicle were performed in the presence of SNP (30 mM; N = 5) or in the presence of urothelium (N = 4). Results are expressed as the net effect of sildenafil where the effect of its vehicle has been subtracted. The data are mean ± SEM of N bladders. Vehicle versus ODQ: ###P < 0.001, two-way anova followed by a modified post hoc Student's t-test with the Bonferroni adjustment for multiple comparisons **P < 0.01; ***P < 0.001, at the concentrations shown.