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. 2010 Jul;160(5):1135–1143. doi: 10.1111/j.1476-5381.2010.00748.x

Figure 5.

Figure 5

Effect of the combination of MDL-12,330A and ODQ on sildenafil-induced relaxation on carbachol-induced human detrusor contraction. Concentration–response curves to sildenafil or vehicle were performed in the presence of MDL-12,330A (10 µM; N = 17) or ODQ (10 µM; N = 17), or the combination of both (N = 6) or vehicle (N = 20) on carbachol (1 µM)-induced detrusor contraction. Results are expressed as the net effect of sildenafil where the effect of its vehicle has been subtracted. The data are mean ± SEM of N bladders. Vehicle versus MDL-12.330A or vehicle versus ODQ: ###P < 0.001, two-way anova. Vehicle versus MDL-12.330A + ODQ: & & &P < 0.001, two-way anova followed by Bonferroni post-test: †P < 0.05; at the concentrations shown. MDL-12,330A versus ODQ: & & &P < 0.001, two-way anova followed by Bonferroni post-test: §P < 0.05; §§P < 0.001 at the concentrations shown.