Table 1.
Effect of ODQ and/or SNAP on carbachol-induced contractions on human detrusor
| ODQ | − | − | − | − | + | + | + | + |
|---|---|---|---|---|---|---|---|---|
| SNAP | − | − | + | + | − | − | + | + |
| CRC sildenafil | − | + | − | + | − | + | − | + |
| Level of contraction induced by carbachol (mg) | 2644 ± 496 | 2644 ± 495 | 2674 ± 446 | 2681 ± 305 | 1976 ± 543 | 2361 ± 519 | 2066 ± 663 | 3058 ± 1323 |
| Maximal inhibition (%) | 12.7 ± 1.8 | 62.1 ± 2.3a | 8.9 ± 2.4b | 51.5 ± 3.5a | 14.0 ± 1.8b | 49.5 ± 3.8a | 10.5 ± 2.7b | 55.3 ± 6.0a |
| Number of experiments | 20 | 20 | 10 | 10 | 17 | 17 | 7 | 7 |
Levels of contraction induced by carbachol were not significantly different between each condition (one-way anova).
a
P < 0.0001, Student's t-test versus corresponding vehicle condition.
b
Non-significant versus first column.