Table 2.
Effect of SNP or urothelium on carbachol-induced contractions on human detrusor
| Urothelium | − | − | − | − | + | + |
|---|---|---|---|---|---|---|
| SNP | − | − | + | + | − | − |
| CRC sildenafil | − | + | − | + | − | + |
| Level of contraction induced by carbachol (mg) | 1289 ± 196 | 2092 ± 435 | 2157 ± 1007 | 2655 ± 900 | 1049 ± 204 | 1021 ± 155 |
| Maximal inhibition (%) | 15.6 ± 3.1 | 57.1 ± 4.6a | 19.5 ± 5.6b | 55.8 ± 7.3a | 15.3 ± 2.2b | 53.8 ± 9.1a |
| Number of experiments | 10 | 10 | 5 | 5 | 4 | 4 |
Levels of contraction induced by carbachol were not significantly different between each condition (one-way anova).
a
P < 0.0001, Student's t-test versus corresponding vehicle condition.
b
Non-significant versus first column.