Table 3.
Effect of MDL-12,330A and/or SNAP on carbachol-induced contractions on human detrusor
| MDL-12,330A | − | − | − | − | + | + | + | + |
|---|---|---|---|---|---|---|---|---|
| SNAP | − | − | + | + | − | − | + | + |
| CRC sildenafil | − | + | − | + | − | + | − | + |
| Level of contraction induced by carbachol (mg) | 2868 ± 455 | 2816 ± 456 | 3246 ± 547 | 3122 ± 624 | 2204 ± 435 | 2377 ± 359 | 2272 ± 907 | 3043 ± 820 |
| Maximal inhibition (%) | 13.8 ± 1.9 | 62.1 ± 2.3a | 9.01 ± 2.1b | 53.2 ± 3.5a | 19.4 ± 2.1b | 44.2 ± 2.5a | 15.6 ± 2.7b | 49.5 ± 4.6a |
| Number of experiments | 20 | 20 | 9 | 9 | 17 | 17 | 6 | 6 |
Levels of contraction induced by carbachol were not significantly different between each condition (one-way anova).
a
P < 0.0001, Student's t-test versus corresponding vehicle condition.
b
Non-significant versus first column.