Table 4.
Effect of the combination of MDL-12,330A and ODQ on carbachol-induced contractions on human detrusor
| MDL-12,330A | − | − | − | − | + | + | + | + |
|---|---|---|---|---|---|---|---|---|
| ODQ | − | − | + | + | − | − | + | + |
| CRC sildenafil | − | + | − | + | − | + | − | + |
| Level of contraction induced by carbachol (mg) | 2868 ± 455 | 2816 ± 456 | 1976 ± 543 | 2361 ± 519 | 2204 ± 435 | 2377 ± 359 | 2168 ± 709 | 1926 ± 541 |
| Maximal inhibition (%) | 13.8 ± 1.9 | 62.1 ±2.3a | 14.0 ± 1.8b | 49.5 ± 3.8a | 19.4 ± 2.1b | 44.2 ± 2.5a | 21.3 ± 2.8c | 47.4 ± 5.2a |
| Number of experiments | 20 | 20 | 17 | 17 | 17 | 17 | 6 | 6 |
Levels of contraction induced by carbachol were not significantly different between each condition (one-way anova).
a
P < 0.001, Student's t-test versus corresponding vehicle condition.
b
Non-significant versus first column.
c
P < 0.05 versus first column.