Table 5.
Effect of K+ channel modulators on carbachol-induced contractions on human detrusor
| K+channel inhibitor | − | − | Glibenclamide | Glibenclamide | Iberiotoxin | Iberiotoxin | Apamin | Apamin |
|---|---|---|---|---|---|---|---|---|
| CRC sildenafil | − | + | − | + | − | + | − | + |
| Level of contraction induced by carbachol (mg) | 3437 ± 654 | 3931 ± 661 | 2852 ± 912 | 3064 ± 879 | 2641 ± 570 | 2970 ± 396 | 3392 ± 1030 | 3756 ± 833 |
| Maximal inhibition (%) | 14.0 ± 2.4 | 59.4 ± 2.3a | 18.9 ± 0.8b | 42.6 ± 3.8a | 11.8 ± 2.5b | 49.9 ± 1.4a | 12.2 ± 2.5b | 50.5 ± 3.4a |
| Number of experiments | 10 | 10 | 7 | 7 | 9 | 9 | 7 | 7 |
Levels of contraction induced by carbachol were not significantly different between each condition (one-way ANOVA).
Vehicle used for drug pre-incubation was a mixture of each drug's vehicle i.e DMSO 0.1%, acetic acid 5 µM and distilled water.
a
P < 0.0001, Student's t-test versus corresponding vehicle condition.
b
Non significant versus first column.