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RSCL-0520 suppresses LPS-induced TNF-α release in Balb/c mice. Balb/c mice (five animals per group) weighing ∼25–30 g were injected i.p. with LPS (225 µg·mL−1) with and without pretreatment of RSCL-0520 (10 and 20 mg·kg−1). RSCL-0520 was injected i.p., 30 min before LPS injection. Then, 1 h after LPS injection, blood was collected retro-orbitally under anaesthesia and serum analysed for TNF-α (***P < 0.001; LPS treated versus RSCL-0520 + LPS treated).
