Figure 13.

RSCL-0520 inhibits carrageenan-induced paw oedema in Wistar rats. The hind paws of rats (weighing ∼180–200 g) were injected with 1% carrageenan in saline (100 µL) to induce oedema. Then, 100 µL of vehicle (PBS) without carrageenan served as a vehicle control. RSCL-0520 (10 or 20 mg·kg⁻¹) was injected i.p., 30 min prior to carrageenan injection in the test animals. Using a plethysmometer, the oedema induced was measured as increase in paw volume, at 0, 2, 4 and 6 h after carrageenan. They were compared with the pre-injection volume of the same paw against the untreated foot of the same rat which served as a reference. % Inflammation was then calculated in control and in drug-treated animals. Values are means ± SEM from two independent experiments with five rats in each experiment. ***P < 0.001, significantly different from values without RSCL-0520.