Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A model of the inhibitory effect of metformin in PMA-induced migration and invasion. This scheme delineates signalling steps identified in the present study. Metformin significantly suppressed MMP-9 activation by blocking the Ca2+ influx and the PKCα/ERK and JNK/AP-1-signalling pathways, and consequent reductions in migration and invasion of human fibrosarcoma cells were identified.
