Table 1.

Summary of MABP and HR in rats given saline or CBD either prior to (time −10 min) ischaemia (performed at time 0 min), or prior to reperfusion (at +30 min)

Time (min)	Vehicle	CBD-PI (10 µg·kg−1)	CBD-PI (50 µg·kg−1)	CBD-PR (50 µg·kg−1)
MABP (mmHg)
−25	132 ± 3	119 ± 12	133 ± 4	127 ± 3
−10	132 ± 3	115 ± 8a	134 ± 4a	128 ± 2
−5	131 ± 3	113 ± 9	118 ± 5†	127 ± 3
0	128 ± 3	110 ± 10	132 ± 2	129 ± 3
1	87 ± 5***	79 ± 7***	90 ± 5***	97 ± 5***
3	94 ± 6***	89 ± 7**	97 ± 5***	108 ± 5**
20	105 ± 4**	80 ± 5***	112 ± 4**	112 ± 4*b
25	107 ± 4**	86 ± 8**	111 ± 3**	110 ± 3*
30	106 ± 4**	80 ± 9***	108 ± 3**	106 ± 2*
31	103 ± 4	89 ± 11	109 ± 8	86 ± 8††
35	109 ± 4	95 ± 12	116 ± 6	97 ± 5
60	110 ± 5	92 ± 13	118 ± 3	101 ± 5
150	98 ± 3	99 ± 7	112 ± 3	108 ± 4
HR (BPM)
−25	438 ± 10	387 ± 35	404 ± 21	426 ± 13
−10	429 ± 8	412 ± 33a	392 ± 20a	429 ± 12
−5	431 ± 8	460 ± 35	396 ± 23	428 ± 15
0	429 ± 8	413 ± 48	401 ± 24	426 ± 15
1	429 ± 7	482 ± 26	406 ± 20	429 ± 13
3	425 ± 9	490 ± 48	404 ± 21	431 ± 13
20	401 ± 12	397 ± 52	383 ± 20	409 ± 15b
25	394 ± 9	430 ± 38	386 ± 20	418 ± 12
30	394 ± 9	445 ± 35	387 ± 22	411 ± 15
31	384 ± 9	464 ± 26	393 ± 22	418 ± 13
35	386 ± 9	476 ± 26	382 ± 27	406 ± 16
60	380 ± 10	420 ± 17	380 ± 23	414 ± 14
150	380 ± 11	426 ± 27	389 ± 18	416 ± 13

^a,bCBD administered.

^†P < 0.05

^††P < 0.01 versus pre-injection value.

^*P < 0.05

^**P < 0.01

^***P < 0.001 versus pre-ischaemic value.

CBD, (-)-cannabidiol; CBD-PI, pre-ischaemia CBD-treated group; CBD-PR, pre-reperfusion CBD-treated group; HR, heart rate; MABP, mean arterial blood pressure.