Table 3.

Adjusted mean baseline total hip BMD, BMC, and area by quintile of sex hormone measures

	Quintile					P value for trend
	1	2	3	4	5
Total estradiol
BMD (g/cm2)	0.940c	0.956a	0.965	0.959	0.979	0.002
BMC (g)	41.26	41.71	42.39	41.37	42.25	0.22
Area (cm2)	43.86a	43.56	43.89a	43.14	43.16	0.02
BioE2
BMD (g/cm2)	0.933d	0.954b	0.955b	0.970	0.987	<0.0001
BMC (g)	41.18a	41.69	41.51	42.25	42.37	0.03
Area (cm2)	44.08b	43.62	43.39	43.54	42.97	0.004
Estrone
BMD (g/cm2)	0.943c	0.944c	0.969	0.954b	0.986	0.0002
BMC (g)	41.60	41.42a	42.17	41.08b	42.71	0.15
Area (cm2)	44.04a	43.84	43.43	43.03	43.30	0.004
Total testosterone
BMD (g/cm2)	0.962	0.971	0.959	0.961	0.946	0.11
BMC (g)	41.30	41.76	41.93	42.28	41.73	0.33
Area (cm2)	42.88	43.01	43.72a	43.95b	44.05b	0.0001
BioT
BMD (g/cm2)	0.957	0.959	0.956	0.973	0.954	0.76
BMC (g)	41.24	41.43	41.60	42.56a	42.16b	0.03
Area (cm2)	43.11	43.15	43.43	43.76	44.16	0.001
SHBG
BMD (g/cm2)	0.974	0.963	0.957	0.973	0.932c	0.007
BMC (g)	41.53	42.25	41.39	42.61	41.21	0.85
Area (cm2)	42.61	43.87c	43.24	43.77b	44.10d	0.0004

All results are adjusted for age, race, clinic, and weight. For pairwise tests, quintile 5 is the referent quintile for estradiol, and quintile 1 is the referent quintile for testosterone and SHBG. Quintile cutoffs were as follows: total estradiol, quintile 1 (<61.3 pmol/liter), quintile 2 (61.3–74.2 pmol/liter), quintile 3 (74.2–87.0 pmol/liter), quintile 4 (87.0–104.6 pmol/liter), and quintile 5 (≥104.6 pmol/liter); BioE2, quintile 1 (<39.7 pmol/liter), quintile 2 (39.7–48.1 pmol/liter), quintile 3 (48.1–56.0 pmol/liter), quintile 4 (56.0–66.0 pmol/liter), and quintile 5 (≥66.0 pmol/liter); estrone, quintile 1 (<86.2 pmol/liter), quintile 2 (86.2–106.5 pmol/liter), quintile 3 (106.5–127.6 pmol/liter), quintile 4 (127.6–159.1 pmol/liter), and quintile 5 (≥159.1 pmol/liter); total testosterone, quintile 1 (<9.81 nmol/liter), quintile 2 (9.81–12.17 nmol/liter), quintile 3 (12.17–14.70 nmol/liter), quintile 4 (14.70–18.17 nmol/liter), and quintile 5 (≥18.17 nmol/liter); BioT, quintile 1 (<5.43 nmol/liter), quintile 2 (5.43–6.56 nmol/liter), quintile 3 (6.56–7.47 nmol/liter), quintile 4 (7.47–8.78 nmol/liter), and quintile 5 (≥8.78 nmol/liter); and SHBG, quintile 1 (<33.3 nmol/liter), quintile 2 (33.3–42.6 nmol/liter), quintile 3 (42.6–50.9 nmol/liter), quintile 4 (50.9–62.9 nmol/liter), and quintile 5 (≥62.9 nmol/liter). P values are for pairwise tests vs. the referent quintile. 

^aP < 0.05. 

^bP < 0.01. 

^cP < 0.001. 

^dP < 0.0001.